Erie Lab

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Dual Resonance Frequency Enhanced Electrostatic Microscopy (DREEM)

Dual Resonance Frequency Enhanced Electrostatic Microscopy (DREEM) is a variant of electrostatic force microscopy (EFM), which is an AFM based technique. A schematic illustration of the technique and sample images are shown below. Read more in the published article.

Combined AFM and Fluorescence Microscopy Technique

AFM is a powerful technique for studying protein-protein and protein-DNA interactions. However, a significant limitation to AFM and other high-resolution microscopy is the difficulty of identifying different proteins in multi-protein complexes. To resolve this, we are interested in combining the … Read more

Past Studies of Transcription Elongation

Utilizing pre-steady state kinetics with various other biochemical techniques, the Erie lab worked toward a better understanding of the process and regulation of transcription elongation. Our past projects included:

AFM Studies of DNA Repair – Overview

AFM provides us unique capability in revealing structural and functional relationship of DNA repair, including but not limited to, the specificity of the protein binding complex, the binding affinity, the DNA bending through bend angle analysis, the conformation analysis, and how … Read more

Lab Gallery

Computer Space - Computer rules in this wasteland...
Art rendering of DNA Repair - I love how fast you can slide, but could you not derail where there were broken rails?(Art from fellow graduate student, adapted from Internet)
Bond of Friendship - When you have fires in your hearts, you can breeze in some cold air
Fluorescence Microscope: (Chinglish) I'll give you some colors to see see if you don't work hard 🙂
Atomic Force Microscope - (In)famously known as the torture chamber, the AFM reveals more than the Chamber of Secrets.
Snows - This is why we like Chapel Hill ... don't have to work when it snows
Asylum AFM - Legend tells of a legendary AFM tip ... When you have that savior tip, you don't need to seek for Asylum (AFM) any more.
Four Colors Fluorescence Microscope - Known as Quad-View, this four eyed monster sees better than your average four eyed nerds.
Backyard - The backyard of the lab is always so peaceful