Dual Resonance Frequency Enhanced Electrostatic Microscopy (DREEM) is a variant of electrostatic force microscopy (EFM), which is an AFM based technique. A schematic illustration of the technique and sample images are shown below. Read more in the published article.

AFM is a powerful technique for studying protein-protein and protein-DNA interactions. However, a significant limitation to AFM and other high-resolution microscopy is the difficulty of identifying different proteins in multi-protein complexes. To resolve this, we are interested in combining the … Read more

AFM provides us unique capability in revealing structural and functional relationship of DNA repair, including but not limited to, the specificity of the protein binding complex, the binding affinity, the DNA bending through bend angle analysis, the conformation analysis, and how … Read more